GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1926657 | 1 | rs4773847 | chr13:95868009 | ABCC4 | chr13:95672084-95953687:- | -0.19 | -3.64 | 0.000303 | Breast cancer |
| THCA | cis | rs1926657 | 1 | rs4773848 | chr13:95873394 | ABCC4 | chr13:95672084-95953687:- | -0.18 | -3.51 | 0.000493 | Breast cancer |
| THCA | cis | rs1926657 | 1 | rs4773854 | chr13:95879410 | ABCC4 | chr13:95672084-95953687:- | -0.19 | -3.49 | 0.000525 | Breast cancer |
| THCA | cis | rs1926657 | 1 | rs4773857 | chr13:95884048 | ABCC4 | chr13:95672084-95953687:- | -0.19 | -3.5 | 0.000505 | Breast cancer |
| THCA | cis | rs7178424 | 1 | rs4775457 | chr15:62374915 | VPS13C | chr15:62144592-62352647:- | -0.1 | -3.79 | 0.000167 | Height |
| THCA | cis | rs7178424 | 1 | rs4775458 | chr15:62375036 | VPS13C | chr15:62144592-62352647:- | -0.1 | -3.79 | 0.000167 | Height |
| THCA | cis | rs3105593 | 1 | rs4775893 | chr15:50898695 | SPPL2A | chr15:50999739-51057910:- | 0.26 | 7.11 | 4.24E-12 | QT interval |
| THCA | cis | rs3105593 | 1 | rs4775897 | chr15:50944066 | SPPL2A | chr15:50999739-51057910:- | 0.28 | 7.34 | 9.28E-13 | QT interval |
| THCA | cis | rs3105593 | 1 | rs4775897 | chr15:50944066 | TRPM7 | chr15:50852491-50978994:- | 0.11 | 3.43 | 0.000663 | QT interval |
| THCA | cis | rs477692 | 1 | rs477692 | chr10:131426022 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.84 | 1.57E-28 | Response to temozolomide |
| THCA | cis | rs477895 | 1 | rs477895 | chr11:64048912 | PRDX5 | chr11:64085569-64089282:+ | 0.16 | 4.47 | 9.86E-6 | Mean platelet volume |
| THCA | cis | rs472402 | 1 | rs477930 | chr5:6635882 | NSUN2 | chr5:6599355-6633157:- | 0.19 | 4.15 | 3.88E-5 | Response to amphetamines |
| THCA | cis | rs1560104 | 1 | rs4780465 | chr16:12707523 | CPPED1 | chr16:12753657-12897744:- | 0.16 | 4.02 | 6.64E-5 | Obesity-related traits |
| THCA | cis | rs683250 | 1 | rs478048 | chr11:83324320 | CCDC90B | chr11:82972506-82997414:- | -0.16 | -3.84 | 0.000139 | Subcortical brain region volumes |
| THCA | cis | rs4265793 | 1 | rs4782193 | chr16:19035682 | COQ7 | chr16:19078927-19091350:+ | -0.29 | -3.94 | 9.54E-5 | Response to angiotensin II receptor blocker therapy |